Premium Sialic Acid for Pharmaceutical Intermediates: 99% Purity Guaranteed CAS22900-11-4

• Customization: Available
• CAS No.: 22900-11-4
• Formula: C12h21no9
• Model NO.: 22900-11-4
• Packaging Material: Paper
• Storage Method: Normal
• Shelf Life: >12 Months
• Nutrient Composition: Mineral
• Resource: Natural
• The content of active substances: ＞90%
• Appearance: White Powder
• Smell: Odorless
• Assay(Converted on Dry Basis): 99.65%
• Optical Rotation: -32.1°
• Heavy Metal: <10ppm
• Transport Package: 1kg/Bag; 25kg/Carton; 50kg/Drum
• Specification: >99%
• Trademark: Zhengshuo Biotech
• Origin: China
• HS Code: 2932999099
• Production Capacity: 10 Tons/Year

Product Description

Product Description

N-Acetylneuraminic acid methyl ester, elegantly abbreviated as Neu5Ac-Me, is a sophisticated derivative of N-acetylneuraminic acid (NANA), a prominent member of the sialic acid family. Sialic acids are essential nine-carbon sugars frequently located on the outer surfaces of cells and glycoproteins, especially within the glycocalyx, the carbohydrate-rich layer that envelops cells, as well as on glycolipids. These sialic acids are pivotal in numerous biological functions, most notably in cellular recognition, signaling, and immunity. Their involvement in these critical pathways underscores their importance in both health and disease management, making them indispensable in pharmaceutical and biotechnological applications.
 

Detailed Photos

Function

Key Characteristics and Properties of N-Acetylneuraminic Acid Methyl Ester (Neu5Ac-Me):
Structural CompositionN-Acetylneuraminic acid (NANA) is a remarkable derivative of neuraminic acid and serves as the most prevalent form of sialic acid found in nature's bounty. When the carboxyl group of NANA undergoes esterification with a methyl group (-OCH3), an exquisite transformation occurs, giving rise to N-acetylneuraminic acid methyl ester (Neu5Ac-Me). This innovative methyl ester modification is frequently utilized in cutting-edge scientific research to enhance the stability of NANA, as well as to modify its reactivity or solubility, opening pathways to novel applications.
Biological RoleSialic acids, such as the renowned N-acetylneuraminic acid (NANA) , play pivotal roles in an array of biological processes, including the essential functions of cell-cell communication, modulation of the immune system, and the intricate process of viral recognition. These acids are prominently located at the tips of glycan chains, where they can profoundly influence protein folding, receptor binding, and the immune response, showcasing their critical importance in biological systems.
The versatile methyl ester form (Neu5Ac-Me) acts as an exemplary model compound for exploring these complex interactions or for ingeniously altering sialic acid's characteristics to suit specific, tailored applications.

Application

Research Applications:Neu5Ac-Me stands as a cornerstone in advanced biochemical and molecular biology research, most notably in the pioneering field of glycobiology (a fascinating domain dedicated to exploring the structure, function, and biology of carbohydrates) and glycomics (the comprehensive study of the carbohydrate components of living organisms).
It serves as an essential reagent in the synthesis of sialylated compounds and is crucial for examining the interactions between sialic acids and lectins (specialized carbohydrate-binding proteins) or pathogens (including viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester form of NANA offers enhanced stability and ease of handling in laboratory conditions, making it an invaluable asset for chemical and enzymatic research.
Potential Use in Drug Development: Given the pivotal role of sialic acids in various critical cellular processes, N-acetylneuraminic acid methyl ester is poised for potential therapeutic breakthroughs. Scientific investigations are delving into sialic acid derivatives for their ability to modulate immune responses, combat infections (by obstructing viral adhesion), and target specific cancer cells. For instance, the infection mechanism of viruses like influenza or enteric pathogens (including E. coli and Norovirus) hinges on their ability to bind to sialic acid residues on host cells. By strategically modifying or inhibiting these interactions, sialic acid derivatives hold promise for groundbreaking antiviral and antimicrobial applications.
Synthesis: Neu5Ac-Me is masterfully synthesized via the chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This transformative modification alters the chemical properties of NANA, enhancing its solubility, stability, and reactivity in diverse chemical processes.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) boasts superior stability compared to free NANA, which is susceptible to degradation. This enhanced stability makes Neu5Ac-Me an ideal candidate for applications demanding high stability, such as in precise drug formulations and sophisticated biochemical assays.

Product Parameters

Test Index	Standard Provision	Result
Appearance	White or Similar White Crystalline Powder	White Powder
Smell	Odorless	Odorless
Assay(Converted on Dry Basis)	>99%	99.65%
Purity(by HPLC)	>99%	99.45%
optical rotation	-30°~ -34°	-32.1°
Heavy Metal	<10ppm	<10ppm
Fe	<5ppm	Not Detected
Pb	<0.1mg/kg	Not Detected
Hg	<0.3mg/kg	Not Detected
As	<0.3mg/kg	Not Detected
Cr	<0.3mg/kg	0.088
Transmittance	≥99%	99.5%
PH	1.8-2.3	2.13
Water Content	≤1.0%	0.25%
Ash	≤1.0%	0.46%
Ethanol residue	<0.5%	0.15%
Loss on drying	≤0.5%	0.32%
Total plate count	<100CFU/g	<10CFU/g
Yeast and Molds	<10CFU/g	<10CFU/g
Number of Coliforms	Not Detectable	Not Detected
Staphylococcus Aureus	Not Detectable	Not Detected
Salmonella Count	Not Detectable	Not Detected
Listeria Monocytogenes	Not Detectable	Not Detected
Cronobacter sakazakii	Not Detectable	Not Detected
Bacillus Cereus	<50CFU/g	<10CFU/g
Dibutyl Phthalate	Not Detectable	Not Detected
Conclusion:The products Conforms to in-house

Certifications

Company Profile

Packaging & Shipping

Shipping:Shipping Methods: DHL / FedEx / EMS / By Air

1. For shipments under 50kgs, we recommend using International Express (FedEx/DHL) with our convenient DAP service for seamless delivery;
2. For cargo under 200kgs, air transportation is your best bet, with options for customer pickup or hassle-free door-to-door service;
3. For larger consignments around 2500kgs, sea transportation is the ideal choice, with flexible customer pickup or efficient door-to-door service available;

FAQ

1. What types of ingredients do you supply?

We offer an extensive selection of ingredients designed to meet a variety of needs, including nutraceutical, cosmetic, food-grade, and pharmaceutical intermediates, perfect for diverse formulation requirements.

2. How can I obtain a sample?
To receive a sample prior to placing your first order, we kindly ask you to cover the sample and express fees. The sample cost will be refunded with your initial order, ensuring a smooth and satisfying start to our partnership.

3. Do you provide OEM & ODM service?
Absolutely, we offer comprehensive OEM & ODM services, supported by our proficient R&D team, dedicated to fulfilling your specific demands.

4. To what quality standards do your ingredients comply?
Our ingredients strictly comply with industry-standard quality and safety regulations. We provide thorough adherence documentation, including Certificates of Analysis, available on request to ensure utmost transparency and trust.

5. What is your lead time?
Our standard lead time is 7-10 working days. We are open to discussions for any special requirements to accommodate your unique needs.

6. What are your payment terms?
We offer flexible payment options including T/T, Paypal, and Western Union. Alternative methods can be negotiated to suit your preferences.