| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me serves as an essential cornerstone in the expansive domains of biochemical and molecular biology research, significantly contributing to the specialized field of glycobiology (unveiling the intricate structure, function, and vital biological roles of carbohydrates) and glycomics (investigating the broad and diverse carbohydrate landscapes thriving within living organisms).
It is instrumental in the synthesis of sialylated compounds and is vital for meticulously exploring the interactions between sialic acids and lectins (specialized proteins with precise carbohydrate-binding abilities) or pathogens (including various viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester variant of NANA offers superior handling ease and exceptional stability within laboratory environments, marking it as an invaluable asset in both chemical and enzymatic investigations.
Potential Use in Drug Development:Recognizing the vital role played by sialic acids in a multitude of cellular processes, N-acetylneuraminic acid methyl ester emerges as a promising pillar for therapeutic advancements. Current research endeavors aim to exploit sialic acid derivatives for modulating immune responses, preventing infections (by inhibiting viral adhesion), and potentially targeting cancer cell pathways with precision.For instance, the ability of viruses like the influenza virus or enteric pathogens (including E. coli and Norovirus) to bind sialic acid residues on host cells is integral to their infection process. By refining or obstructing these critical interactions, sialic acid derivatives harbor the potential for revolutionary antiviral or antimicrobial innovations.
Synthesis:Neu5Ac-Me is synthesized through an advanced chemical esterification process involving N-acetylneuraminic acid (NANA) with methylating agents. This transformation bestows NANA with altered chemical properties, enhancing features such as solubility, stability, and reactivity in targeted chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) showcases superior stability over unmodified NANA, which is prone to degradation. As a result, Neu5Ac-Me is indispensable in scenarios demanding unwavering stability, such as in the formulation of pharmaceuticals or in conducting rigorous biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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