| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me stands as a cornerstone in the dynamic fields of biochemical and molecular biology research, where it takes on a vital role in the domain of glycobiology (unraveling the intricate structure, function, and biological significance of carbohydrates) and glycomics (exploring the vast carbohydrate universe within living organisms).
This compound is essential in crafting sialylated compounds and is key to investigating the interactions between sialic acids and lectins (proteins known for their specific carbohydrate-binding affinity) or pathogens (including viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester variant of NANA provides improved handling and exceptional stability in laboratory settings, making it an invaluable asset for both chemical and enzymatic studies.
Potential Use in Drug Development:Recognizing the pivotal role of sialic acids in an array of cellular processes, N-acetylneuraminic acid methyl ester shines as a potential catalyst for therapeutic advancements. Current studies strive to leverage sialic acid derivatives for modulating immune responses, preventing infections (by blocking viral adhesion), and possibly targeting specific cancer cell pathways.For instance, the proficiency of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) in binding to sialic acid residues on host cells underpins the infection process. By refining or obstructing these vital interactions, sialic acid derivatives present the potential for revolutionary antiviral or antimicrobial innovations.
Synthesis:Neu5Ac-Me is produced via the intricate chemical esterification of N-acetylneuraminic acid (NANA) with methylating agents. This modification imparts new chemical properties to NANA, enhancing qualities such as solubility, stability, and reactivity in select chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) exhibits superior stability compared to free NANA, which is prone to degradation. Consequently, Neu5Ac-Me is invaluable in applications demanding consistent stability, such as drug formulations or rigorous biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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