Product Description
N-Acetylneuraminic Acid Dihydrate, also revered as Neu5Ac or NANA, stands as a pivotal compound renowned for its extensive and versatile contributions to the field of biology. Embark on an enlightening exploration with us and discover its indispensable roles within scientific study. Uncover the vast spectrum of applications that underscore its vital significance in pioneering research and cutting-edge innovation. This remarkable compound serves as a cornerstone in advancing our understanding of biological processes, offering unparalleled opportunities for exploration and discovery.
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Function
Cellular Recognition: Neu5Ac, or N-Acetylneuraminic Acid, is a luminary in the realm of cellular biology. It serves as a prestigious enhancer for glycoproteins and glycolipids, which elegantly adorn cell surfaces. This distinguished recognition molecule is the maestro behind the captivating interplay between cells, significantly contributing to the orchestration of immune responses and the sophisticated dance of cell adhesion.
Viral Infection: Neu5Ac emerges as a crucial player in unraveling the enigmatic pathways of viral infections, particularly those instigated by influenza viruses. These cunning viruses strategically target and bind to Neu5Ac on host cells, paving the path for their infectious exploits. Delving into these viral-protein and Neu5Ac interactions heralds a new era in antiviral strategy innovation, illuminating a pathway teeming with potential in combating viral pandemics.
Brain Development: In the intriguing sphere of neuroscience, Neu5Ac proves to be a cornerstone for both brain development and function. As a pivotal component in ganglioside formation, it is omnipresent in neuronal membranes. These gangliosides are indispensable for intricate cell signaling pathways and deliver formidable protection to neurons, highlighting Neu5Ac's critical role in sustaining cognitive health and offering enduring neuroprotection.
Glycosylation: Neu5Ac is an integral player in the sophisticated processes of glycosylation, acting as a vital precursor in the seamless attachment of sugars to proteins or lipids. This biochemical modification is paramount for ensuring the stability, functionality, and recognition of a myriad of biomolecules, thereby safeguarding cellular integrity and vibrant activity.
Application
Research Applications:Neu5Ac-Me is an invaluable cornerstone in biochemical and molecular biology research, serving a vital purpose in the expansive world of glycobiology (unraveling the intricate structure, function, and essential biological roles of carbohydrates) and glycomics (exploring the vast carbohydrate landscape within living organisms).
It is instrumental in the synthesis of sialylated compounds, playing a key role in examining interactions between sialic acids and lectins (proteins with specific carbohydrate affinities) or pathogens (such as viruses and bacteria) that bind to sialic acid residues on host cells. The methyl ester variant of NANA provides enhanced ease of use and exceptional stability under laboratory conditions, making it an essential tool in both chemical and enzymatic research.
Potential Use in Drug Development:Given the pivotal role sialic acids play in a multitude of cellular processes, N-acetylneuraminic acid methyl ester stands as a beacon of promise for innovative therapeutics. Current studies aim to utilize sialic acid derivatives in modulating immune responses, preventing infections (by inhibiting viral adhesion), and selectively targeting cancerous cell pathways.For instance, the proficiency of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) in adhering to sialic acid residues on host cells is essential to their infection process. By refining or obstructing these interactions, sialic acid derivatives hold the potential for revolutionary antiviral or antimicrobial advancements.
Synthesis:Neu5Ac-Me is crafted through the advanced chemical esterification of N-acetylneuraminic acid (NANA) via methylating agents. This transformation imparts new chemical properties to NANA, enhancing attributes like solubility, stability, and reactivity in select chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) exhibits superior stability over free NANA, which may degrade. As a result, Neu5Ac-Me is irreplaceable in scenarios demanding unwavering stability, such as drug formulations or rigorous biochemical analyses.
Product Parameters
| Test Index |
Standard Provision |
Result |
| Appearance |
White or Similar White Crystalline Powder |
White Powder |
| Smell |
Odorless |
Odorless |
| Assay(Converted on Dry Basis) |
>99% |
99.65% |
| Purity(by HPLC) |
>99% |
99.45% |
| optical rotation |
-30°~ -34° |
-32.1° |
| Heavy Metal |
<10ppm |
<10ppm |
| Fe |
<5ppm |
Not Detected |
| Pb |
<0.1mg/kg |
Not Detected |
| Hg |
<0.3mg/kg |
Not Detected |
| As |
<0.3mg/kg |
Not Detected |
| Cr |
<0.3mg/kg |
0.088 |
| Transmittance |
≥99% |
99.5% |
| PH |
1.8-2.3 |
2.13 |
| Water Content |
≤1.0% |
0.25% |
| Ash |
≤1.0% |
0.46% |
| Ethanol residue |
<0.5% |
0.15% |
| Loss on drying |
≤0.5% |
0.32% |
| Total plate count |
<100CFU/g |
<10CFU/g |
| Yeast and Molds |
<10CFU/g |
<10CFU/g |
| Number of Coliforms |
Not Detectable |
Not Detected |
| Staphylococcus Aureus |
Not Detectable |
Not Detected |
| Salmonella Count |
Not Detectable |
Not Detected |
| Listeria Monocytogenes |
Not Detectable |
Not Detected |
| Cronobacter sakazakii |
Not Detectable |
Not Detected |
| Bacillus Cereus |
<50CFU/g |
<10CFU/g |
| Dibutyl Phthalate |
Not Detectable |
Not Detected |
| Conclusion:The products Conforms to in-house |
Certifications
Company Profile
Packaging & Shipping
Shipping:Shipping Method: DHL / FedEx / EMS / By Air
- For shipments weighing less than 50kgs, we highly recommend utilizing International Express with FedEx or DHL. Embrace the convenience of our Delivered-at-Place (DAP) service for a seamless and stress-free delivery experience.
- For packages under 200kgs, opt for air transportation, which is our preferred choice. Experience the flexibility of either customer pick-up or our reliable door-to-door service tailored for your convenience.
- For larger consignments up to 2500kgs, sea transportation is an ideal suggestion. Choose between customer pick-up or indulge in the simplicity of our comprehensive door-to-door service.or indulge in the simplicity of our comprehensive door-to-door service.
FAQ
1. What types of ingredients do you supply?
We offer a diverse and extensive array of ingredients, expertly suited to a broad range of formulation needs. Our selection includes nutraceutical ingredients, cosmetic ingredients, food ingredients, and pharmaceutical intermediates.
2. How can I obtain a sample?
Requesting a sample is straightforward. Simply cover the sample cost and express fee, and we will reimburse the sample cost with your initial purchase, ensuring a risk-free trial.
3. Do you offer OEM & ODM services?
Absolutely, we are proud to offer OEM & ODM services, powered by our expert R&D team, to tailor solutions that fulfill your specific requirements and expectations.
4. What quality standards do your ingredients comply with?
Rest assured, our ingredients adhere to stringent industry-standard quality and safety regulations. We provide full compliance and relevant documentation, including Certificates of Analysis, upon request.
5. What is your lead time?
Our typical lead time is 7-10 working days, ensuring prompt and efficient service. For any special requirements, please feel free to discuss with us to tailor the timeline to your needs.
6. What are your payment terms?
We are flexible with payment options, accepting several methods including T/T, Paypal, Western Union, and more options that can be negotiated to suit your preferences.
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