Customization: | Available |
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CAS No.: | 50795-27-2 |
Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me stands as a cornerstone in the unparalleled world of biochemical and molecular biology research, significantly contributing to the advancement of glycobiology (which unravels the intricate structure, function, and biological significance of carbohydrates) and glycomics (which explores the vast carbohydrate landscapes within living organisms with precision).
It is indispensable in the synthesis of pivotal sialylated compounds and crucial for exploring the dynamics between sialic acids and lectins (proteins with precise carbohydrate-binding abilities) or pathogens (like viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester form of NANA provides superior handling and exceptional stability in laboratory settings, making it an invaluable resource for both chemical and enzymatic studies.
Potential Use in Drug Development:Recognizing the essential role sialic acids play in diverse cellular activities, N-acetylneuraminic acid methyl ester emerges as a promising frontier in the realm of therapeutics. Current research focuses on exploiting sialic acid derivatives to modulate immune responses, prevent infections by obstructing viral adhesion, and potentially disrupt specific cancer cell mechanisms.For instance, the capability of viruses like the influenza virus or enteric pathogens (including E. coli and Norovirus) to bind to sialic acid residues on host cells is central to their infection strategy. By refining or averting these essential interactions, sialic acid derivatives offer the potential for revolutionary antiviral or antimicrobial advancements.
Synthesis:Neu5Ac-Me is artfully synthesized through the intricate chemical esterification process of N-acetylneuraminic acid (NANA) utilizing methylating agents. This chemical transformation enhances NANA's properties, improving aspects like solubility, stability, and reactivity in select chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) exhibits remarkable stability compared to free NANA, which is prone to degradation. Therefore, Neu5Ac-Me becomes essential in applications demanding consistent stability, such as drug formulations or intensive biochemical assays.
Test Index | Standard Provision | Result |
Appearance | White or Similar White Crystalline Powder | White Powder |
Smell | Odorless | Odorless |
Assay(Converted on Dry Basis) | >99% | 99.65% |
Purity(by HPLC) | >99% | 99.45% |
optical rotation | -30°~ -34° | -32.1° |
Heavy Metal | <10ppm | <10ppm |
Fe | <5ppm | Not Detected |
Pb | <0.1mg/kg | Not Detected |
Hg | <0.3mg/kg | Not Detected |
As | <0.3mg/kg | Not Detected |
Cr | <0.3mg/kg | 0.088 |
Transmittance | ≥99% | 99.5% |
PH | 1.8-2.3 | 2.13 |
Water Content | ≤1.0% | 0.25% |
Ash | ≤1.0% | 0.46% |
Ethanol residue | <0.5% | 0.15% |
Loss on drying | ≤0.5% | 0.32% |
Total plate count | <100CFU/g | <10CFU/g |
Yeast and Molds | <10CFU/g | <10CFU/g |
Number of Coliforms | Not Detectable | Not Detected |
Staphylococcus Aureus | Not Detectable | Not Detected |
Salmonella Count | Not Detectable | Not Detected |
Listeria Monocytogenes | Not Detectable | Not Detected |
Cronobacter sakazakii | Not Detectable | Not Detected |
Bacillus Cereus | <50CFU/g | <10CFU/g |
Dibutyl Phthalate | Not Detectable | Not Detected |
Conclusion:The products Conforms to in-house |
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