| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me is an essential powerhouse for the fields of biochemical and molecular biology research, playing a pivotal and transformative role in the realm of glycobiology (exploring the intricate structure, function, and biological importance of carbohydrates) and glycomics (delving into the comprehensive carbohydrate landscape within living organisms).
It is fundamental in the synthesis of sialylated compounds, serving as an essential tool for investigating interactions between sialic acids and lectins (proteins with specific carbohydrate-binding properties) or pathogens (such as viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester variant of NANA, with its superior handling and exceptional stability in laboratory settings, becomes an invaluable asset in both chemical and enzymatic investigations.
Potential Use in Drug Development:Given the critical involvement of sialic acids in a multitude of cellular processes, N-acetylneuraminic acid methyl ester emerges as a beacon of innovation for therapeutic advancements. Current research endeavors aim to utilize sialic acid derivatives for immunomodulation, infection prevention (through viral adhesion inhibition), and selectively targeting cancer cell pathways.For instance, the proficiency of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) to bind to sialic acid residues on host cells is vital for infection processes. By refining or obstructing these crucial interactions, sialic acid derivatives hold the potential for revolutionary antiviral or antimicrobial developments.
Synthesis:Neu5Ac-Me is crafted through the sophisticated chemical esterification of N-acetylneuraminic acid (NANA) using specialized methylating agents. This process results in modified chemical properties for NANA, enhancing characteristics such as solubility, stability, and reactivity in selected chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) offers remarkable stability superior to free NANA, which is prone to degradation. As a result, Neu5Ac-Me is indispensable in situations demanding unwavering stability, including drug formulation and rigorous biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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