| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me stands as a cornerstone in the dynamic fields of biochemical and molecular biology research, serving as a vital catalyst in the advancement of glycobiology (the enthralling study of the complex structure, function, and biological roles of carbohydrates) and glycomics (the comprehensive exploration of carbohydrate landscapes within living organisms).
It is pivotal in synthesizing sialylated compounds and is essential for investigating interactions between sialic acids and lectins (proteins known for their specific carbohydrate binding) as well as pathogens (such as viruses and bacteria) that bind to sialic acid residues on host cells. The methyl ester variant of NANA offers improved handling and exceptional stability in laboratory settings, making it an indispensable tool for chemical and enzymatic studies.
Potential Use in Drug Development:Considering the pivotal role of sialic acids in various cellular processes, N-acetylneuraminic acid methyl ester emerges as a promising element in the forefront of therapeutic advancements. Current research seeks to leverage sialic acid derivatives to modulate immune responses, prevent infections (by inhibiting viral adherence), and potentially target specific cancer cell mechanisms.For instance, the ability of viruses such as the influenza virus or enteric pathogens (including E. coli and Norovirus) to adhere to sialic acid residues on host cells is a crucial aspect of infection. By refining or blocking these essential interactions, sialic acid derivatives hold the potential for groundbreaking antiviral or antimicrobial innovations.
Synthesis:Neu5Ac-Me is produced through the advanced chemical esterification of N-acetylneuraminic acid (NANA) employing methylating agents. This process alters NANA's chemical properties, enhancing characteristics such as solubility, stability, and reactivity in specific chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) offers superior stability compared to free NANA, which is prone to degradation. Thus, Neu5Ac-Me is essential in scenarios demanding consistent stability, like drug formulations or high-precision biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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