| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me is an essential component in the domains of biochemical and molecular biology research, serving a critical function in the field of glycobiology (unveiling the intriguing structure, function, and biological significance of carbohydrates) and glycomics (investigating the vast carbohydrate landscape within living systems).
It is vital in the creation of sialylated compounds and is key for investigating interactions between sialic acids and lectins (proteins known for their precise carbohydrate binding) or pathogens (including viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester variant of NANA provides enhanced manageability and extraordinary stability in laboratory settings, making it an invaluable tool in both chemical and enzymatic studies.
Potential Use in Drug Development:Given the pivotal role of sialic acids in a multitude of cellular processes, N-acetylneuraminic acid methyl ester stands as a hopeful beacon for progress in therapeutics. Ongoing research endeavors to exploit sialic acid derivatives for modulating immune responses, combating infections (by preventing viral adhesion), and possibly targeting specific cancer cell pathways.For instance, the proficiency of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) in binding to sialic acid residues on host cells is fundamental to their infectious mechanisms. By refining or obstructing these crucial interactions, sialic acid derivatives hold the potential for trailblazing antiviral or antimicrobial advancements.
Synthesis:Neu5Ac-Me is synthesized through the advanced chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This transformation results in modified chemical properties for NANA, enhancing characteristics like solubility, stability, and reactivity in specific chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) offers exceptional stability compared to free NANA, which may degrade. As a result, Neu5Ac-Me is indispensable in applications requiring steady stability, such as in drug formulations or demanding biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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