| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is a pivotal component in the expansive fields of biochemical and molecular biology research. It serves as a foundational element in the in-depth exploration of glycobiology (an intricate domain focused on the structure, function, and biological significance of carbohydrates) and glycomics (the exhaustive study of carbohydrate constituents in living systems).
It is crucial for synthesizing sialylated compounds and delving into the sophisticated interactions between sialic acids and lectins (specialized carbohydrate-binding proteins), as well as pathogens (including viruses and bacteria) that interact with sialic acid residues on host cells. The methyl ester variant of NANA is favored for its user-friendly handling and heightened stability in laboratory environments, making it an invaluable resource for chemical and enzymatic research endeavors.
Potential Use in Drug Development:Sialic acids are integral to a multitude of essential cellular processes, and thus, N-acetylneuraminic acid methyl ester shows promising therapeutic possibilities. Preliminary research investigates the potential of sialic acid derivatives in modulating immune responses, treating infections by inhibiting viral binding, and even targeting particular cancer cells.For example, the method by which viruses like influenza or intestinal pathogens (such as E. coli or Norovirus) attach to sialic acid residues on host cells is essential to the infection mechanism. By modifying or obstructing these interactions, sialic acid derivatives could provide notable antiviral or antimicrobial advantages.
Synthesis:Neu5Ac-Me is produced through the chemical esterification of N-acetylneuraminic acid (NANA) utilizing methylating agents. This conversion can alter NANA's chemical properties, including its solubility, stability, and reactivity in diverse chemical processes.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) generally exhibits greater stability compared to free NANA, which is prone to degradation. Therefore, Neu5Ac-Me is beneficial in contexts where stability is crucial, such as in pharmaceutical formulations or complex biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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