| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is extensively utilized in the fascinating fields of biochemical and molecular biology research, acting as a vital pillar in the profound exploration of glycobiology (a sophisticated domain focused on unraveling the mysteries of carbohydrate structures, their functions, and biological significance) and glycomics (an exhaustive investigation into the diverse carbohydrate components present in living organisms).
It holds a crucial role in the synthesis of sialylated compounds while facilitating the in-depth examination of the complex interplay between sialic acids and lectins (specialized proteins that bind carbohydrates) or pathogens (such as viruses and bacteria) that interact with sialic acid residues on host cells. The methyl ester form of NANA is often preferred for its user-friendly handling and superior stability in laboratory environments, making it an invaluable tool for chemical and enzymatic investigations.
Potential Use in Drug Development:Considering that sialic acids are integral to numerous vital cellular processes, N-acetylneuraminic acid methyl ester offers promising potential in therapeutic development. Preliminary studies are delving into the applications of sialic acid derivatives for modulating immune responses, treating infections by inhibiting viral binding, and precision-targeting specific cancer cells.For example, the mechanisms through which viruses like influenza or enteric pathogens (including E. coli and Norovirus) adhere to sialic acid residues on host cell surfaces play a critical role in the infection pathway. By modifying or obstructing these interactions, sialic acid derivatives present considerable antiviral or antimicrobial capabilities.
Synthesis:Neu5Ac-Me is produced through chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This process can alter the chemical characteristics of NANA, enhancing its solubility, stability, and reactivity across various chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) generally exhibits greater stability compared to free NANA, which is prone to degradation. As a result, Neu5Ac-Me is particularly advantageous in scenarios where stability is crucial, such as in pharmaceutical formulations or complex biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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