| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me stands as a pivotal element in the domain of biochemical and molecular biology research, acting as a foundation in the vast exploration of glycobiology (a detailed field that investigates the structure, function, and biological significance of carbohydrates) and glycomics (the thorough study of carbohydrate components present in living organisms).
It is crucial for synthesizing sialylated compounds and analyzing the intricate interactions between sialic acids and lectins (specialized proteins that bind carbohydrates) or pathogens (including viruses and bacteria) that interact with sialic acid residues on host cells. The methyl ester format of NANA is often favored for its user-friendliness and superior stability in laboratory environments, making it a prized resource for chemical and enzymatic studies.
Potential Use in Drug Development:Considering that sialic acids are key players in many crucial cellular operations, N-acetylneuraminic acid methyl ester shows great therapeutic potential. Preliminary research investigates the application of sialic acid derivatives in modulating immune responses, treating infections by inhibiting viral binding, and even targeting specific cancer cells.For example, the process by which viruses such as influenza or enteric pathogens (like E. coli or Norovirus) attach to sialic acid residues on host cells is vital to the infection process. By modifying or blocking these interactions, sialic acid derivatives could provide substantial antiviral or antimicrobial advantages.
Synthesis:Neu5Ac-Me is crafted through the chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This alteration can affect the chemical properties of NANA, such as its solubility, stability, and reactivity in various chemical processes.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) generally exhibits greater stability than free NANA, which is prone to degradation. As a result, Neu5Ac-Me is beneficial in contexts where stability is critical, such as in pharmaceutical formulations or complex biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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