| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is harnessed extensively for its pivotal role in biochemical and molecular biology research, particularly illuminating the intricate world of glycobiology (a fascinating discipline focused on unraveling the structure, function, and biological significance of carbohydrates) and glycomics (the comprehensive study dedicated to understanding the carbohydrate component of living organisms).
Neu5Ac-Me is an invaluable asset in synthesizing sialylated compounds and in investigating the sophisticated interactions between sialic acids and lectins (proteins with a remarkable affinity for binding carbohydrates) or pathogens (including viruses and bacteria) that have a penchant for interacting with sialic acid residues on host cells. The methyl ester form of NANA is often preferred for its ease of handling and enhanced stability under laboratory conditions, making it an indispensable tool for chemical and enzymatic studies.
Potential Use in Drug Development: Given the crucial involvement of sialic acids in numerous vital cellular processes, N-acetylneuraminic acid methyl ester holds promise for therapeutic advancements. Cutting-edge research is exploring sialic acid derivatives for their potential in modulating immune responses, combating infections by obstructing viral binding, or even selectively targeting cancer cells. For instance, the adeptness of viruses such as influenza or enteric pathogens (like E. coli or Norovirus) to attach to sialic acid residues on host cells is a critical step in the infection process. By strategically modifying or inhibiting these interactions, sialic acid derivatives offer potential antiviral or antimicrobial capabilities.
Synthesis: Neu5Ac-Me is adeptly synthesized through the chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This modification distinctly enhances the chemical properties of NANA, such as its solubility, stability, and capacity to engage in specific chemical reactions.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) stands out for its superior stability compared to free NANA, which is susceptible to degradation. Consequently, Neu5Ac-Me is well-suited for environments or applications where stability is paramount, such as in the formulation of drugs or in conducting biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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