| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is an indispensable compound extensively utilized in the realms of biochemical and molecular biology research, specifically in the intricate exploration of glycobiology (the scientific study of the structure, function, and biology of carbohydrates) and glycomics (the comprehensive study of carbohydrate components within living organisms).
This compound is instrumental in the synthesis of sialylated compounds and crucial for studying the interactions between sialic acids and lectins (carbohydrate-binding proteins) or pathogens (including viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester form of NANA offers enhanced handling and stability in laboratory conditions, making it a valuable asset for both chemical and enzymatic studies.
Potential Use in Drug Development: Given the critical role of sialic acids in numerous cellular processes, N-acetylneuraminic acid methyl ester presents promising therapeutic possibilities. Research has explored the application of sialic acid derivatives for immune response modulation, infection treatment (by preventing viral binding), and even targeting specific cancer cells. For instance, viruses like influenza or enteric pathogens (including E. coli and Norovirus) rely on sialic acid residues on host cells for infection. By altering or obstructing these interactions, sialic acid derivatives could potentially exhibit antiviral or antimicrobial properties.
Synthesis: Neu5Ac-Me is synthesized through the chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This modification can significantly alter the chemical characteristics of NANA, influencing its solubility, stability, and reactivity in various chemical reactions.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) is generally more stable than the free form of NANA, which tends to degrade easily. Consequently, Neu5Ac-Me is preferred for applications where stability is paramount, such as in drug formulations and biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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