| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is a cornerstone in the realm of biochemical and molecular biology research, holding particular significance in the intricate study of glycobiology (the fascinating exploration into the structure, function, and biology of carbohydrates) and glycomics (which delves into the carbohydrate component of living organisms).
This compound shines in the synthesis of sialylated compounds and is pivotal in unraveling the interactions between sialic acids and lectins (the specialized carbohydrate-binding proteins) or pathogens (including viruses and bacteria) that target sialic acid residues on host cells. Notably, the methyl ester form of NANA offers enhanced handling and stability under laboratory conditions, making it an indispensable tool for both chemical and enzymatic research.
Potential Use in Drug Development: Given the vital role of sialic acids in numerous critical cellular processes, N-acetylneuraminic acid methyl ester holds promise for therapeutic applications. Extensive research is exploring how sialic acid derivatives could revolutionize immune response modulation, infection treatment (by effectively blocking viral binding), and even the targeting of specific cancer cells. For instance, the binding capability of viruses like influenza or enteric pathogens (such as E. coli or Norovirus) to sialic acid residues on host cells is crucial for infection. By ingeniously modifying or obstructing these interactions, sialic acid derivatives could potentially offer groundbreaking antiviral or antimicrobial benefits.
Synthesis: Neu5Ac-Me synthesis is elegantly achieved through chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This innovative modification can alter NANA's chemical properties, enhancing its solubility, stability, and reactivity in specific chemical reactions.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) stands out with superior stability compared to free NANA, which is susceptible to degradation. Consequently, Neu5Ac-Me emerges as the compound of choice in scenarios demanding high stability, such as in cutting-edge drug formulations or precise biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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