| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is a pivotal compound extensively utilized in the realms of biochemical and molecular biology research, offering invaluable insights especially within the study of glycobiology (the fascinating exploration of the structure, function, and biology of carbohydrates) and glycomics (the comprehensive study of the carbohydrate components within living organisms).
This compound plays a crucial role in the synthesis of sialylated compounds and facilitates the study of intricate interactions between sialic acids and lectins (specialized carbohydrate-binding proteins) or pathogens (including viruses and bacteria) that interact with sialic acid residues on host cells. The methyl ester form of NANA is particularly advantageous, as it may offer enhanced handling ease or increased stability under laboratory conditions, thus serving as a vital tool for both chemical and enzymatic studies.
Potential Use in Drug Development: Given the fundamental role of sialic acids in numerous critical cellular processes, N-acetylneuraminic acid methyl ester emerges as a compound with promising therapeutic potential. Groundbreaking research is exploring the potential of sialic acid derivatives in modulating immune responses, tackling infections (by thwarting viral attachment), and even targeting specific cancer cells. For instance, the ability of viruses like influenza or enteric pathogens (such as E. coli or Norovirus) to bind to sialic acid residues on host cells is a critical aspect of infection. By modifying or obstructing these interactions, sialic acid derivatives hold potential as powerful antiviral or antimicrobial agents.
Synthesis: Neu5Ac-Me is crafted through the precise chemical esterification of N-acetylneuraminic acid (NANA) utilizing methylating agents. This sophisticated modification alters the chemical characteristics of NANA, including parameters such as solubility, stability, and its capacity to engage in specific chemical reactions.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) is renowned for its superior stability compared to free NANA, which is susceptible to degradation. Consequently, Neu5Ac-Me becomes the compound of choice for applications where stability is paramount, such as in precise drug formulations or intricate biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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