| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is widely employed in the realms of biochemical and molecular biology research, serving as a cornerstone in the expansive study of glycobiology (an intricate field exploring the structure, function, and biological roles of carbohydrates) and glycomics (the comprehensive study of the carbohydrate components in living organisms).
It plays an essential role in synthesizing sialylated compounds and examining the complex interactions between sialic acids and lectins (specialized carbohydrate-binding proteins) or pathogens (including viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester variant of NANA is often preferred for its ease of handling and enhanced stability in laboratory settings, rendering it a valuable asset for chemical and enzymatic research.
Potential Use in Drug Development: Given that sialic acids play a pivotal role in numerous essential cellular functions, N-acetylneuraminic acid methyl ester holds promising therapeutic potential. Early research explores the utility of sialic acid derivatives in immune response modulation, infection treatment through viral binding inhibition, and even targeting specific cancer cells. For instance, the mechanism by which viruses like influenza or enteric pathogens (such as E. coli or Norovirus) adhere to sialic acid residues on host cells is crucial to the infection process. By altering or preventing these interactions, sialic acid derivatives could offer significant antiviral or antimicrobial benefits.
Synthesis: Neu5Ac-Me is synthesized through chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This transformation can modify the chemical attributes of NANA, such as its solubility, stability, and reactivity in various chemical processes.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) is generally more stable than free NANA, which is susceptible to degradation. Consequently, Neu5Ac-Me is advantageous in situations where stability is paramount, such as in pharmaceutical formulations or intricate biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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