| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is widely embraced in the realms of biochemical and molecular biology research, serving as a pivotal tool in unraveling the mysteries of glycobiology (the intricate study of the structure, function, and the biological roles of carbohydrates) and glycomics (the comprehensive exploration of carbohydrate components within living organisms).
Its role in the chemical synthesis of sialylated compounds and the investigation of sialic acids' interactions with lectins (proteins dedicated to binding carbohydrates) or pathogens (such as viruses and bacteria) that engage with sialic acid residues on host cells is invaluable. The methyl ester form of NANA offers enhanced handling ease and stability under laboratory conditions, making it a preferred choice for chemical and enzymatic research.
Potential Use in Drug Development: Given the critical roles sialic acids play in numerous cellular processes, N-acetylneuraminic acid methyl ester holds promise for therapeutic innovations. Studies have explored sialic acid derivatives to modulate immune responses, combat infections by inhibiting viral binding, and even target specific cancer cells. For instance, the ability of viruses like influenza or enteric pathogens (such as E. coli or Norovirus) to adhere to sialic acid residues on host cells is essential for infection. By altering or obstructing these interactions, sialic acid derivatives show potential as antiviral or antimicrobial agents.
Synthesis: Neu5Ac-Me is synthesized through the chemical esterification of N-acetylneuraminic acid (NANA) utilizing methylating agents. Such modification can alter the chemical properties of NANA, enhancing aspects like solubility, stability, and reactivity in specific chemical reactions.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) stands out for its superior stability compared to free NANA, which is susceptible to degradation. Consequently, Neu5Ac-Me is ideal for environments or applications demanding steadiness, notably in drug formulations or complex biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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