| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me is an essential cornerstone in the expansive fields of biochemical and molecular biology research, playing a particularly crucial role for glycobiology (where we delve into the sophisticated world of carbohydrate structures, their functions, and biological significance) and glycomics (which explores the extensive carbohydrate landscape within living organisms).
It is instrumental in the synthesis of sialylated compounds and in examining the interactions between sialic acids and lectins (proteins that have a specific affinity for carbohydrates) or pathogens (including viruses and bacteria) that interact with sialic acid residues on host cells. The methyl ester variant of NANA provides improved handling convenience and stability in laboratory settings, making it an indispensable asset in both chemical and enzymatic research.
Potential Use in Drug Development:Given the pivotal role of sialic acids in a myriad of cellular processes, N-acetylneuraminic acid methyl ester emerges as a promising prospect for therapeutic innovation. Research is actively exploring the potential of sialic acid derivatives to modulate immune responses, combat infections by preventing viral adherence, and target specific cancer cell pathways.For example, the ability of viruses such as the influenza virus or enteric pathogens (including E. coli or Norovirus) to bind to sialic acid residues on host cells is central to the infection process. By refining or interrupting these vital interactions, sialic acid derivatives hold the potential for significant antiviral or antimicrobial advancements.
Synthesis:Neu5Ac-Me is ingeniously crafted through the intricate chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This transformation results in modified chemical properties for NANA, elevating characteristics such as solubility, stability, and reactivity in specific chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) is distinguished by its enhanced stability compared to free NANA, which is prone to degradation. Consequently, Neu5Ac-Me is invaluable in situations demanding consistent stability, such as in pharmaceutical formulations or demanding biochemical experiments.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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