Product Description
N-Acetylneuraminic Acid Dihydrate, affectionately known as Neu5Ac or NANA, is a cornerstone compound in the realm of biology, celebrated for its formidable versatility and profound contributions. Embark on an enlightening exploration with us to reveal its indispensable roles across numerous scientific applications. Discover the profound significance of Neu5Ac in pioneering research and groundbreaking innovation, underscoring its pivotal impact on modern biological studies and advancements.
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Function
Cellular Recognition: Neu5Ac, scientifically known as N-Acetylneuraminic Acid, is a cornerstone in the captivating world of cellular biology. This extraordinary molecule enhances glycoproteins and glycolipids that adorn the cell surfaces with elegance. It stands as a key recognition molecule, orchestrating enchanting intercellular interactions and serving a pivotal role in immune responses and the intricate dance of cell adhesion.
Viral Infection: Neu5Ac plays a critical role in unraveling the complexities of viral infections, especially those instigated by cunning influenza viruses. These viruses target and bind to Neu5Ac on host cells, facilitating their infectious quest. Delving into the intricate viral-protein and Neu5Ac interactions paves the way for groundbreaking antiviral strategy innovations, offering a guiding light in the relentless battle against viral outbreaks.
Brain Development: In the mesmerizing domain of neuroscience, Neu5Ac is essential for brain development and optimal functionality. It acts as a crucial building block in the synthesis of gangliosides, which are richly present in neuronal membranes. These gangliosides are indispensable for cell signaling pathways and provide robust protection to neurons, highlighting Neu5Ac's vital role in maintaining cognitive health and advancing neuroprotection.
Glycosylation: Neu5Ac stands as a vital component in the glycosylation processes, serving as an indispensable precursor for the attachment of sugars to proteins or lipids. This fundamental biochemical modification ensures the stability, functionality, and recognition of countless biomolecules, thereby safeguarding the integrity and activity of cells.
Application
Research Applications:Neu5Ac-Me is an indispensable asset in the realms of biochemical and molecular biology research, playing a pivotal role in the field of glycobiology (where we delve into the intricate structure, function, and biological significance of carbohydrates) and glycomics (focusing on the vast carbohydrate landscape within living organisms).
It plays a crucial role in the synthesis of sialylated compounds, essential for probing interactions between sialic acids and lectins (proteins specialized in carbohydrate binding) or pathogens (including viruses and bacteria) that interact with sialic acid residues on host cells. The methyl ester variant of NANA provides enhanced handling and superior stability under laboratory conditions, making it an invaluable tool in chemical and enzymatic explorations.
Potential Use in Drug Development:Given the pivotal role of sialic acids in various cellular processes, N-acetylneuraminic acid methyl ester emerges as a beacon of hope in advancing therapeutics. Current studies aim to harness sialic acid derivatives to modulate immune functions, combat infections by inhibiting viral adhesion, and potentially target specific cancer cell pathways.For instance, the skill of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) in binding to sialic acid residues on host cells is crucial to the infection process. By refining or blocking these critical interactions, sialic acid derivatives have the potential to usher in groundbreaking antiviral or antimicrobial innovations.
Synthesis:Neu5Ac-Me is synthesized through sophisticated chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This transformation alters NANA's chemical properties, enhancing its solubility, stability, and reactivity in specific chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) offers superior stability compared to free NANA, which can degrade. As a result, Neu5Ac-Me is essential in scenarios demanding unwavering stability, such as in drug formulations or rigorous biochemical assays.
Product Parameters
| Test Index |
Standard Provision |
Result |
| Appearance |
White or Similar White Crystalline Powder |
White Powder |
| Smell |
Odorless |
Odorless |
| Assay(Converted on Dry Basis) |
>99% |
99.65% |
| Purity(by HPLC) |
>99% |
99.45% |
| optical rotation |
-30°~ -34° |
-32.1° |
| Heavy Metal |
<10ppm |
<10ppm |
| Fe |
<5ppm |
Not Detected |
| Pb |
<0.1mg/kg |
Not Detected |
| Hg |
<0.3mg/kg |
Not Detected |
| As |
<0.3mg/kg |
Not Detected |
| Cr |
<0.3mg/kg |
0.088 |
| Transmittance |
≥99% |
99.5% |
| PH |
1.8-2.3 |
2.13 |
| Water Content |
≤1.0% |
0.25% |
| Ash |
≤1.0% |
0.46% |
| Ethanol residue |
<0.5% |
0.15% |
| Loss on drying |
≤0.5% |
0.32% |
| Total plate count |
<100CFU/g |
<10CFU/g |
| Yeast and Molds |
<10CFU/g |
<10CFU/g |
| Number of Coliforms |
Not Detectable |
Not Detected |
| Staphylococcus Aureus |
Not Detectable |
Not Detected |
| Salmonella Count |
Not Detectable |
Not Detected |
| Listeria Monocytogenes |
Not Detectable |
Not Detected |
| Cronobacter sakazakii |
Not Detectable |
Not Detected |
| Bacillus Cereus |
<50CFU/g |
<10CFU/g |
| Dibutyl Phthalate |
Not Detectable |
Not Detected |
| Conclusion:The products Conforms to in-house |
Certifications
Company Profile
Packaging & Shipping
Shipping:Shipping Method: DHL / FedEx / EMS / By Air
- For shipments weighing less than 50kgs, we highly recommend utilizing International Express with FedEx or DHL. Embrace the convenience of our Delivered-at-Place (DAP) service for a seamless and stress-free delivery experience.
- For packages under 200kgs, opt for air transportation, which is our preferred choice. Experience the flexibility of either customer pick-up or our reliable door-to-door service tailored for your convenience.
- For larger consignments up to 2500kgs, sea transportation is an ideal suggestion. Choose between customer pick-up or indulge in the simplicity of our comprehensive door-to-door service.or indulge in the simplicity of our comprehensive door-to-door service.
FAQ
1. What types of ingredients do you supply?
We offer a diverse and extensive array of ingredients, expertly suited to a broad range of formulation needs. Our selection includes nutraceutical ingredients, cosmetic ingredients, food ingredients, and pharmaceutical intermediates.
2. How can I obtain a sample?
Requesting a sample is straightforward. Simply cover the sample cost and express fee, and we will reimburse the sample cost with your initial purchase, ensuring a risk-free trial.
3. Do you offer OEM & ODM services?
Absolutely, we are proud to offer OEM & ODM services, powered by our expert R&D team, to tailor solutions that fulfill your specific requirements and expectations.
4. What quality standards do your ingredients comply with?
Rest assured, our ingredients adhere to stringent industry-standard quality and safety regulations. We provide full compliance and relevant documentation, including Certificates of Analysis, upon request.
5. What is your lead time?
Our typical lead time is 7-10 working days, ensuring prompt and efficient service. For any special requirements, please feel free to discuss with us to tailor the timeline to your needs.
6. What are your payment terms?
We are flexible with payment options, accepting several methods including T/T, Paypal, Western Union, and more options that can be negotiated to suit your preferences.
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