| Customization: | Available |
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| CAS No.: | 22900-11-4 |
| Formula: | C12h21no9 |
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Research Applications:Neu5Ac-Me is used extensively in biochemical and molecular biology research, particularly in the study of glycobiology (the study of the structure, function, and biology of carbohydrates) and glycomics (the study of the carbohydrate component of living organisms).
It can be used in the synthesis of sialylated compounds and in the study of interactions between sialic acids and lectins (carbohydrate-binding proteins) or pathogens (such as viruses and bacteria) that interact with sialic acid residues on host cells.The methyl ester form of NANA may be easier to handle or more stable in laboratory conditions, making it a useful tool for chemical and enzymatic studies.
Potential Use in Drug Development: Because sialic acids are involved in many critical cellular processes, N-acetylneuraminic acid methyl ester may have potential therapeutic uses. Research has looked into the use of sialic acid derivatives for modulating immune responses, treating infections (by blocking viral binding), or even targeting certain cancer cells. For example, the ability of viruses like influenza or enteric pathogens (such as E. coli or Norovirus) to bind to sialic acid residues on host cells is a key part of infection. By modifying or blocking these interactions, sialic acid derivatives could potentially have antiviral or antimicrobial effects.
Synthesis: Neu5Ac-Me can be synthesized through chemical esterification of N-acetylneuraminic acid (NANA) with methylating agents. This modification can change the chemical properties of NANA, such as its solubility, stability, and ability to participate in certain chemical reactions.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) is typically more stable than free NANA, which is prone to degradation. As a result, Neu5Ac-Me may be used in environments or applications where stability is critical, such as in drug formulations or biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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