| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me is an indispensable asset in the realms of biochemical and molecular biology research, playing a pivotal role in the field of glycobiology (exploring the fascinating structure, function, and biological role of carbohydrates) and glycomics (delving into the extensive carbohydrate landscape within living organisms).
It plays a crucial role in the synthesis of sialylated compounds and is indispensable for probing interactions between sialic acids and lectins (proteins that exhibit specific carbohydrate binding) or pathogens (such as viruses and bacteria) that interact with sialic acid residues on host cells. The methyl ester variant of NANA offers enhanced handling and remarkable stability under laboratory conditions, rendering it an invaluable tool in both chemical and enzymatic explorations.
Potential Use in Drug Development:Given the crucial role of sialic acids in numerous cellular processes, N-acetylneuraminic acid methyl ester emerges as a beacon of hope for advancing therapeutics. Ongoing investigations aim to harness sialic acid derivatives for modulating immune functions, thwarting infections (by inhibiting viral adhesion), and potentially targeting selective cancer cell pathways.For example, the adeptness of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) in binding to sialic acid residues on host cells is crucial to infection processes. By refining or blocking these critical interactions, sialic acid derivatives hold the promise of groundbreaking antiviral or antimicrobial breakthroughs.
Synthesis:Neu5Ac-Me is synthesized through the sophisticated chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This transformation results in altered chemical properties for NANA, enhancing attributes like solubility, stability, and reactivity in select chemical reactions.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) boasts superior stability compared to free NANA, which can degrade. Consequently, Neu5Ac-Me proves indispensable in scenarios where unwavering stability is required, such as in drug formulations or rigorous biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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