| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me serves as an essential cornerstone in biochemical and molecular biology research, especially vital within glycobiology (which explores the complex architecture, roles, and functions of carbohydrates) and glycomics (delving into the expansive carbohydrate universe within biological organisms).
It is indispensable in synthesizing sialylated compounds and examining the interactions of sialic acids with lectins (specific carbohydrate-binding proteins) or pathogens (including viruses and bacteria) that target sialic acid residues on host cells. The methyl ester form of NANA enhances ease of handling and stability in laboratory environments, positioning it as a vital component in both chemical syntheses and enzymatic studies.
Potential Use in Drug Development:Owing to the significant role of sialic acids in diverse cellular mechanisms, N-acetylneuraminic acid methyl ester emerges as a promising candidate for therapeutic innovation. Research is actively exploring the use of sialic acid derivatives to modulate immune responses, inhibit infectious processes (by preventing viral adhesion), and potentially influence specific cancer cell pathways.For example, the capability of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) to bind sialic acid residues on host cells is central to infection. By modifying or blocking these key interactions, sialic acid derivatives offer the potential for groundbreaking antiviral or antimicrobial therapies.
Synthesis:Neu5Ac-Me is synthesized through advanced chemical esterification of N-acetylneuraminic acid (NANA) utilizing methylating agents. This conversion results in modified chemical characteristics, improving properties such as solubility, stability, and reactivity in specific chemical processes.
Stability and Application:N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) is distinguished by its exceptional stability compared to free NANA, which is prone to degradation. As a result, Neu5Ac-Me is crucial in applications requiring stable conditions, such as in pharmaceutical preparations or sophisticated biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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