| Customization: | Available |
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| CAS No.: | 50795-27-2 |
| Formula: | C11h23no11 |
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Research Applications:Neu5Ac-Me is an indispensable asset in the realms of biochemical and molecular biology research, particularly pivotal for glycobiology (delving into the intricate world of the structure, function, and biological role of carbohydrates) and glycomics (exploring the vast carbohydrate landscape within living organisms).
It plays a crucial role in the synthesis of sialylated compounds and in probing the interactions between sialic acids and lectins (proteins that bind specifically to carbohydrates) or pathogens (such as viruses and bacteria) that engage with sialic acid residues on host cells. The methyl ester variant of NANA offers enhanced handling ease and stability under laboratory conditions, making it an invaluable tool in both chemical and enzymatic explorations.
Potential Use in Drug Development: Given the critical involvement of sialic acids in numerous cellular processes, N-acetylneuraminic acid methyl ester emerges as a beacon of hope for therapeutic advancements. Investigations are underway to leverage sialic acid derivatives in modulating immune functions, combating infections (by thwarting viral adhesion), and potentially targeting selective cancer cell pathways. For instance, the adeptness of viruses like the influenza virus or enteric pathogens (such as E. coli or Norovirus) in binding to sialic acid residues on host cells forms the crux of infection processes. By refining or obstructing these critical interactions, sialic acid derivatives hold the promise of antiviral or antimicrobial breakthroughs.
Synthesis: Neu5Ac-Me is crafted through the sophisticated chemical esterification of N-acetylneuraminic acid (NANA) using methylating agents. This transformation culminates in altered chemical properties for NANA, enhancing attributes like solubility, stability, and reactivity in select chemical reactions.
Stability and Application: N-Acetylneuraminic acid methyl ester (Neu5Ac-Me) stands out for its superior stability compared to free NANA, which is susceptible to degradation. Consequently, Neu5Ac-Me proves indispensable in scenarios demanding unwavering stability, such as in drug formulations or rigorous biochemical assays.
| Test Index | Standard Provision | Result |
| Appearance | White or Similar White Crystalline Powder | White Powder |
| Smell | Odorless | Odorless |
| Assay(Converted on Dry Basis) | >99% | 99.65% |
| Purity(by HPLC) | >99% | 99.45% |
| optical rotation | -30°~ -34° | -32.1° |
| Heavy Metal | <10ppm | <10ppm |
| Fe | <5ppm | Not Detected |
| Pb | <0.1mg/kg | Not Detected |
| Hg | <0.3mg/kg | Not Detected |
| As | <0.3mg/kg | Not Detected |
| Cr | <0.3mg/kg | 0.088 |
| Transmittance | ≥99% | 99.5% |
| PH | 1.8-2.3 | 2.13 |
| Water Content | ≤1.0% | 0.25% |
| Ash | ≤1.0% | 0.46% |
| Ethanol residue | <0.5% | 0.15% |
| Loss on drying | ≤0.5% | 0.32% |
| Total plate count | <100CFU/g | <10CFU/g |
| Yeast and Molds | <10CFU/g | <10CFU/g |
| Number of Coliforms | Not Detectable | Not Detected |
| Staphylococcus Aureus | Not Detectable | Not Detected |
| Salmonella Count | Not Detectable | Not Detected |
| Listeria Monocytogenes | Not Detectable | Not Detected |
| Cronobacter sakazakii | Not Detectable | Not Detected |
| Bacillus Cereus | <50CFU/g | <10CFU/g |
| Dibutyl Phthalate | Not Detectable | Not Detected |
| Conclusion:The products Conforms to in-house | ||
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